Sepsis
Meronem dose is easier than Tienam in renal failure
As a clinical pharmacy specialist, doctors will often ask you about the difference between Meronam and Tienam . And how to adjust the doses of each in patients with kidney impairment... Imipenem ( Tienam ) is the first carbapenem, was marketed in 1987. It is more active against Gram-positive cocci. While meropenem ( Meronem ) is more a…
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Sepsis
Empiric antimicrobial management of sepsis
DEFINITIONS ㅡ Bacteremia is simply the presence of bacteria in the blood. Systemic inflammatory response syndrome ( SIRS ) is denoted by two or more of the following clinical symptoms, (1) Body temperature > 38°C or < 36°C, (2) heart rate > 90 beats per minute, (3) respiratory rate > 20 breaths per minute or PaCO2 (partial pressure of carbon dioxide i…
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Nephrology and Urology
Antibiotic dosing requirements in patients with chronic kidney disease and dialysis
OVERVIEW ― We're getting questions about how to dose oral antibiotics with dialysis since medication labels and references may conflict or be murky. KEY POINTS Recommend usual doses of antibiotics that aren't renally cleared including azithromycin, clindamycin, and doxycycline. But advise adjusting other antib…
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