Pharmacology
Allopurinol
Class: Xanthine Oxidase Inhibitor; Antigout Dosage Forms. Tablet: 100 mg, 200 mg, 300 mg MOA. Allopurinol decreases the production of uric acid by inhibiting the action of xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid. …
قراءة المزيد
Rheumatology
Recommend allopurinol instead of febuxostat for most chronic gout patients
AS A PHARMACIST, you'll hear about an advocacy group pushing for withdrawal of the gout med febuxostat ( Uloric, Xanthistop ) due to concerns it increases mortality. FDA adds Boxed Warning for increased risk of death with gout medicine Uloric (febuxostat), available at: https://www.fda.gov/drugs/drug-safety-and-availability/fda-adds-boxed-warning-increased-ri…
قراءة المزيد
Rheumatology
Allopurinol or febuxostat for chronic gout?
As a pharmacist, you’ll get questions about managing chronic gout due to continued debate over whether to aim for a target uric acid level. We know to consider a chronic medication to lower uric acid when gout causes problems such as tophi or 2 or more acute gout flares/year. But there’s not much evidence on the best way to titrate medications. Some “treat to target”…
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Rheumatology
Comparison of GOUT therapies
G out is one of the most common forms of arthritis. It occurs more often in men. During a gout attack, high uric acid levels lead to the formation of uric acid crystals in joints (usually knees, ankles, and feet; can affect elbows, wrists, and fingers). Symptoms can include pain, redness, joint swelling and limited range of motion, and fever. Gout risk factors inc…
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