One of the most ADVERSE EFFECT caused by calcium channel blockers (CCD), dihydropyridine (e.g., amlodipine, etc) is peripheral edema. It's dose-dependent. Incidence of peripheral edema may be > 80% with high doses. Major cause of CCB nonadherence. Mechanism is thought to be arteriolar dilatation. The resulting pressure gradient between arteriole and venule ca…
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