As a critical care pharmacist, questions are still popping up about seizure prophylaxis after a neurological injury, trauma, intracranial hemorrhage, etc. Who should get it? Continue to use seizure prophylaxis after a SEVERE traumatic brain injury (TBI); Glasgow Coma Scale 3 to 8. About 1 in 10 TBI patients have seizures…
قراءة المزيدPhenytoin ( Epanutin, Epilog ) is one of the most difficult drugs to dose. This is because phenytoin metabolism depends on the dose. Higher doses take longer to metabolize, so doubling the dose can more than double the serum concentration. Follow these steps... Loading doses help get to therapeutic levels faster. Give 15 to 20 mg/kg PO or IV, about 1000 mg fo…
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