Quetiapine
Stronger WARNINGS about quetiapine and QT prolongation
As a clinical pharmacist, you will see stronger warnings about quetiapine ( Seroquel , etc) and QT prolongation. Many of the antipsychotics can prolong the QT interval , but not all of them are associated with torsades or sudden death. Torsades with quetiapine is very rare, and usually linked to an overdose. But the problem is that you can't predict who will get …
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SSRIs
Limiting doses of citalopram
As a hospital or community pharmacist, you will hear about limiting doses of citalopram ( Cipram , etc). Experts say citalopram doses should not exceed 40 mg/day for anyone, or 20 mg/day for most patients over age 60. Higher doses of citalopram increase the risk of QT prolongation and the life-threatening arrhythmia, torsades. …
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QT prolongation
Avoid QT-prolonging medications in HIGH-risk patients
As a hospital pharmacist, you will get questions about which medications or combos can "tip the balance" and lead to problems with QT prolongation. Many commonly used medications can prolong the QT interval. But it rarely leads to torsades and sudden death in low-risk patients on one QT drug. Watch for the highest-risk patients, where torsa…
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Side Effects
Pay attention when quinolones used in diabetic patients
Stronger WARNINGS will lead to more concerns about quinolone risks . Quinolone labels already caution about hypo- and hyperglycemia, and certain CNS effects such as agitation, nervousness, or confusion. Now FDA will require warnings of hypoglycemic coma especially in the elderly, renal impairment, or in combination with …
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SSRIs
Depression and cardiovascular disease
Introduction ― Depression is common in patients with cardiovascular (CV) disease. Symptoms of depression are seen in 65% of patients after an acute myocardial infarction (MI). Major depressive disorder is diagnosed in up to 20% of patients after an acute coronary syndrome. Depression is associated with a doubling in the risk of a cardiovascular event within one to t…
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SSRIs
Address depression in patients after a heart attack
How to treat depression after a heart attack? this is important questions. Depression occurs in nearly half of heart attack patients and it's associated with a higher risk of CV events and death. Plus adherence to lifestyle changes and cardiovascular medications, antiplatelets, statins, etc may be even harder for patients with depression. But don't recommend …
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