Vancomycin
The optimal treatment for MRSA bacteremia in adults
As a hospital pharmacist, you will ask yourself questions about the optimal treatment for methicillin-resistant Staph aureus (MRSA) bacteremia in adults. Consider these strategies when treating your patients... Continue to use vancomycin first. Daptomycin is also first-line, but there's no good evidence it works better, and it co…
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Vancomycin
Monitor VANCOMYCIN with AUC/MIC goals
As a hospital pharmacist, you will see a shift toward monitoring vancomycin using AUC/MIC calculations instead of trough levels. Clinical pharmacists normally aim for troughs of 15 to 20 mg/L for serious MRSA infections, to increase the likelihood of AUC/MIC over 400. But it turns out these troughs can overshoot AUC/MIC goals and are linked to more nephrotoxicity. …
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Vancomycin
First-line for clostridium difficile, vancomycin or fidaxomicin?
Debate will brew about FIRST-LINE medications for C. difficile based on differing recommendations in new guidelines. Oral metronidazole has fallen out of favour, because it's less effective than vancomycin. The American College of Gastroenterology now recommends either oral vancomycin or fidaxomicin for a first C. difficile episode. In contr…
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