Vitamin-B12 Deficiency
Best approach for treating megaloblastic anemia
BACKGROUND ㅡ Megaloblastic anemia is characterized by red blood cells (RBCs) that are larger than normal and caused by B12 or folic acid deficiency, drugs, or genetic disorders. In certain populations such as patients from India, B12 deficiency is higher (> 75%), probably due to the largely vegetarian diet. Patients with meglobastic anemia can have higher homocys…
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Vitamin-B12 Deficiency
Consider more use of INTRAVENOUS iron to patients
As a pharmacist, you'll see expanded use of IV iron in medical patients. More experts are advocating for IV iron replacement beyond patients with chronic kidney disease (CKD). This is due to faster repletion, poor tolerability of oral iron and low adverse event risk. A typical dose in a non-CKD patient is 1,000 mg over one hour. We know to consider IV iron when o…
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Vitamin-B12 Deficiency
Iron deficiency anemia (IDA)
O verview ― Iron deficiency is present if serum ferritin is < 12 ng/mL or < 30 ng/mL if also anemic. In adults, caused by bleeding unless proved otherwise. Causes include blood loss (gastrointestinal, menstrual, repeated blood donation), deficient diet or decreased absorption of iron and increased requirements (pregnancy, lactation). Women with heavy menstrual…
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Vitamin-B12 Deficiency
Overview of anemia
Screening ― Do not perform routine screening for anemia in nonpregnant, asymptomatic patients. Although determination of hemoglobin concentration or hematocrit is important to evaluating a variety of complaints (e.g., fatigue, weight loss, abdominal pain, GI bleeding) and may provide clues in asymptomatic patients to presence of treatable disease (e.g., GI malignancy…
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Vitamin-B12 Deficiency
Management of vitamin B12 deficiency
Overview ㅡ Vitamin B12 ( cobalamin ) is necessary for a variety of critical functions within the human body (e.g., blood cell production, DNA synthesis, and neurologic function). Dietary sources of cobalamin are mainly found in animal products and fortified foods (e.g., Cereal). Vitamin B12 deficiency is a common problem, especially in the elderly. It is one of the …
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